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HPVIS Ad hoc Query

Selection of Columns

STEP 2: Select one or more column(s) for your output by clicking on the square box next to the column name. When you are finished selecting columns, click on the "STEP 3: Enter Search Criteria" button at the bottom of this page.

QUERY NAME: Mammalian Health Endpoints, TABLE NAME: V_MAMMALIAN_EZ
	Animals at Final Sacrifice	The number of animals examined at the final sacrifice.
	Animals at Interim Sacrifice	The number of animals examined at the interim sacrifice.
	Body Fluids Sampled	All bodily fluids monitored by the study.
	Carcinogenic Effect	An indicator of the carcinogenicity of the chemical tested.
	CAS Number	A standardized number assigned by the Chemical Abstracts Service (CAS) to identify a chemical (e.g., 10595-60-5).
	Category Chemical	The system generated ID for the category chemical for which the study is being performed.
	Challenge Exposure Period	Duration of the challenge portion of the test.
	Challenge Exposure Period Units	Time units represented by the exposure period value.
	Challenge Frequency of Treatment	Description of the administration of doses to the test animals during the challenge phase of the test (e.g., n doses per per week).
	Chemical Category Name	The name of the chemical category.
	Clinical Observations	Additional information that may be needed for an adequate assessment of data reliability. Provide, at a minimum, qualitative descriptions of observations indicating dose-related effects: 1. Body Weight 2. Food/Water Consumption 3. Identity, Severity, Time of Onset (e.g., date/time of day, days after exposure) and Duration of Clinical Signs 4. Clinical chemistry (e.g., hematology, urinalysis), if possible 5. Other examination, e.g., Enzyme Induction, Cell Proliferation, Reversibility of Effects
	Concentration Percentage	Percentage of test test subjects impacted by the observed concentration.
	Concentration Result Type	An indicator signifying whether the value reported is a lethal concentration of an effective concentration.
	Concentration Units	The unit of the concentration of the substance in water during the pH determination, preferably in mg/L.
	Concentration Upper Value	The upper concentration value.
	Concentration Value	Concentration that causes the indicated effect on the indicated percentage of the test subjects.
	Concentration Value Description	The mathematical symbol to describe the measured/estimated lethal concentration.
	Conclusion	Sponsor's characterization of whether the validity criteria of the test guidelines followed can be considered fulfilled for Genetic Toxicity in vitro.
	Conclusion	Sponsor's characterization of whether the validity criteria of the test guidelines followed can be considered fulfilled.
	Conjunctivae (Chemosis)	Irritation score.
	Conjunctivae (Redness)	Irritation score.
	Consortium Name	The names of the companies that belong to the consortium or partnership if applicable.
	Control Group Type	Describe the concurrent controls used in the study
	Cornea Irritation	Irritation score.
	Details on Cytogenetic Assay	Any details that could be relevant for evaluating this study summary or that are requested by the respective regulatory programme. Consult the programme-specific guidance (e.g. OECD HPVC, Pesticides NAFTA or EU REACH) thereof.
	Dose Remarks	Information about the Doses or Concentrations applied to the test subjects.
	Edema	Irritation score.
	Endpoint Name	The specific endpoint about which data is reported.
	Erythema	Irritation score.
	Excretion Routes	Excretion routes monitored by the study.
	Exposure Period	Duration of the test.
	Exposure Period Units	Time units represented by the exposure period value.
	Exposure Period Upper Value	Upper duration of the test.
	Final Sacrifice Time	The number of weeks following the initiation of the study when the final sacrifice occurred.
	Frequency of Treatment	Description of the administration of doses to the test animals (e.g., n doses per day, n days per week).
	Gender	Gender of the tested animals.
	Genotoxic Effect	Description of study results for each dose/concentration level.
	Genotoxic Effect	Description of study results for each dose/concentration level.
	GLP	Indicate if the study was conducted following Good Laboratory Practice standards. Enter Not Applicable for studies involving estimated values.
	Grade	Grade determined for the result.
	Grading Scale	Identify the scale/grading system used.
	Interim Sacrifice Time	The number of weeks following the initiation of the study when the interim sacrifice occurred.
	Interpretation of Results	Overall interpretation of or conclusions drawn from the test results.
	Iris Irritation	Irritation score.
	Key Study Sponsor Indicator	An indicator entered by the sponsor specifying whether or not the Robust Summary's test results for this endpoint are summarized from a "key" or "critical" study.
	Lesions	Description of lesions, if seen.
	Limit Test	An indicator that the experiment was a limit test.
	Mammalian Strain	Strain of mammal tested.
	Measurement Period	Measurement time applicable to the test result value.
	Measurement Period Units	Time units represented by the measurement period value.
	Metabolic Activation	Indicate whether metabolic activation was applied or not. Select "not applicable" for mammalian cell lines when no exogenous metabolic system is required for Genetic Toxicity in vitro.
	Metabolic Activation	Identify use of mammalian metabolism in non-mammalian (in vitro) experiments.
	Metabolites Excreted	List all the excreted metabolites.
	Metabolites in Body Fluids	List all the metabolites found in sampled body fluids.
	Metabolites in Tissues	List all the metabolites found in sampled tissues.
	Method/Guideline Followed	The name of the Method or Guideline followed in performing the study.
	MTD Indicator	Was Maximum Tolerated Dose (MTD) reached or exceeded?
	Negative Control Substance	Identify the negative control used in the test.
	Neoplastic Effect	Describe the benign or malignant neoplasm.
	Ninth Collective Chemical Index Name	A standardized chemical name taken from the Ninth Collective Index for the CAS Number.
	Number of Animals per Sex and Dose Group	Textual description of the number of animals dosed per sex and dose group
	Number of Deaths Females	Number of female animals that died per dose/concentration.
	Number of Deaths Males	Number of male animals that died per dose/concentration.
	Number of Deaths Total	Number of animals that died per dose/concentration. The sum of male and female deaths if reported by gender, otherwise the total number of non-gender specific deaths.
	Number of Organisms per Dose/Concentration	The number of organisms dosed at each dose level of the study.
	Other Endpoint Description	Any additional pertinent information about a non-standard Endpoint.
	Other Endpoint Name	The name assigned by the submitter to the Endpoint when it is not one of the existing system defined Endpoint Names.
	Other Route of Administration	How the chemical was administered to the test animals for non-standard methods.
	Other Species	Identify the species tested for Genetic Toxicity in vitro.
	Other Species	Identify the species tested when not available from the list of standard species.
	Other Strain	The mammalian strain tested, when not available from the list of standard strains.
	Other Strain	The mammalian strain tested, when not available from the list of standard strains for Genetic Toxicity in vitro.
	Other Vehicle Name	Chemical identity of a non-standard vehicle.
	Overall Irritation Score	Total of the individual irritation measures.
	Percent Sensitized -- Negative Control	Percentage of the test subjects sensitized by exposure to this dosage of the negative control substance.
	Percent Sensitized -- Positive Control	Percentage of the test subjects sensitized by exposure to this dosage of the positive control substance.
	Percent Sensitized -- Test Substance	Percentage of the test subjects sensitized by exposure to this dosage.
	Population	The population of test subjects in whom the referenced effect was observed.
	Positive Control Substance	Identify the positive control used in the test.
	Positive, Negative and Solvent Control Substance(s)	Indicate whether a positive, negative and solvent control substance was used in this study. If yes, please indicate the postive, negative and solvent control substance. Also describe the validity of the positive, negative and solvent control substance tests.
	Post-Exposure Period Value Description	The mathematical symbol to describe the measured/estimated value.
	Post-Exposure/Depuration Period	Observation period after last exposure to the test chemical.
	Post-Exposure/Depuration Period Units	Time units represented by the post-exposure period value.
	Pre-Mating Exposure Period for Females	Number of days females dosed prior to mating.
	Pre-Mating Exposure Period for Males	Number of days males dosed prior to mating.
	Preparation of Test Site	Indicator whether test site was shaved or abraded.
	Primary Irritation Index	Note the Irritation Index score.
	Program Flag	Program that the submission is associated with.
	Reliability	Indication of the adequacy of data at the discretion of the person preparing the Robust Summary.
	Reliability Remarks	Comments about how the reliability of data was determined and other related remarks. If a numeric or other coded system, such as Klimisch Codes are used to denote reliability, identify and/or define the coding system.
	Remarks	Comments, discussions, or other related EPA remarks.
	Results Remarks	Sponsor provided additional descriptive text about the results of the study.
	Route of Administration	How the chemical was administered to the test animal.
	Route of Challenge Exposure	Indicate the route of challenge exposure.
	Route of Induction	Indicate the route of induction exposure.
	Sensitization Score	Numeric characterization of the Sensitization properties of the test substance at this dosage, ranging from 0 (no Sensitization potential) to 4.
	Species	Organism/cell culture used in the experiment.
	Species or in Vitro System	Organism/cell culture used in the experiment.
	Sponsor Name	The name of the individual company or consortium (i.e., two or more companies) making a commitment in the HPV Challenge Program to provide data for a chemical or category of chemicals (e.g., Eastman Chemical Company).
	Sponsored Chemical Result Type	Indicator showing whether the test result represents a measured or an estimated value for the sponsored chemical.
	Statistical Results	Note statistical results, with appropriate p value and 95% Confidence Limit.
	Strain	Strain of the tested species for Genetic Toxicity in vitro.
	Study Reference	Identify reference(s) used to compile the summary by entering: author(s), year, title, laboratory name, laboratory report number, report date (if published, list journal name, volume, pages).
	Study Type	Type of experiment performed.
	Submission Name	The sponsor provided name associated with the submission.
	Submitter's Name	The name of the individual company or consortium formally providing test plan related information.
	Survival Rate Females	Percentage of female animals that survived per dose/concentration.
	Survival Rate Males	Percentage of male animals that survived per dose/concentration.
	Survival Rate Total	Percentage of animals that survived per dose/concentration.
	Systemic Toxicity	The effect of a substance on body tissues after absortion into the bloodstream.
	Test Conditions Remarks	Additional comments describing the characteristics of the Test Conditions.
	Test or Estimation Type	Type of test or estimation performed.
	Test Substance ID	The system generatedl ID of the chemical substance actually used to perform the test (sponsored or supporting).
	Test Substance Purity	The purity of the chemical used in the study or estimation. Not applicable to mixtures. Note if not available.
	Test Type	Type of test performed.
	Tissues Sampled	All bodily tissue types monitored by the study.
	Tool	Tool used to asses the irritation scores.
	Total Volume Applied	The total volume of active/test substance applied/instilled.
	Total Volume Applied Units	The unit of measure applied to the total value of active/test substance.
	Type of Coverage	Indicator whether the test material was covered on the site applied to.
	Type of Exposure	Further definition of dose administration.
	Type of Study	Indicate the type of study regardless of whether it is already specified in the guideline, as this field can be used for query purposes.
	Type of Test	Names a specific genetic toxicity test type, which is a refinement of the genotoxicity study type.
	Unable to Measure or Estimate Justification	A short description of why neither a measured test result nor estimated value will be provided for this endpoint.
	Vehicle Amount	The amount of carrier/solvent used to deliver the test substance to the experimental system.
	Vehicle Name	Chemical identity of the vehicle
	Vehicle Units	Units of measure describing the Vehicle Amount.
	Vehicle Used	Indicator that a chemical was used to emulsify or mix the experimental chemical to enhance its solubility.
	Year Study Performed	If known, the sponsor provided year in which the test being described was conducted.

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